What is Lefno 20mg (LEFLUNOMIDE)?
DMARD for rheumatoid arthritis and psoriatic arthritis. Second-line after methotrexate failure or intolerance. Once-daily dosing due to long half-life of active metabolite.
How it Works
Prodrug converted to teriflunomide — inhibits DHODH, blocking de novo pyrimidine synthesis in proliferating T and B cells — reduces immune-mediated joint inflammation.
Quick Specs
| Form | Oral tablets — pre-dosed |
| Active Ingredient | LEFLUNOMIDE |
| Dose per Tablet | 20MG |
| Pack Size | 10×10 (100 tablets) |
| Storage | Room temperature (15–25°C), cool dry place |
| Shelf Life | 2–3 years (properly stored) |
Common Side Effects
Diarrhea (most common), nausea, hair loss (usually mild), rash, elevated liver enzymes, hypertension, peripheral neuropathy (rare).
Safety Warnings
⚠️ TERATOGENIC — pregnancy absolutely contraindicated. Accelerated elimination procedure (cholestyramine) required before pregnancy. Hepatotoxicity monitoring — especially combined with methotrexate.
🌏 International shipping: 7–14 days
