Tadalafil: What It Is, How It Works & Research Data | QSC
QSC RESEARCH COMPOUND
Tadalafil
PDE5 inhibitor studied for smooth muscle cGMP biology and vasodilation research.
≥99% HPLC Purity MS Confirmed Janoshik COA Research Use Only
What is Tadalafil?
Tadalafil is a selective PDE5 inhibitor with the longest half-life of any approved PDE5 inhibitor (~17.5 hours). Structurally distinct from sildenafil (β-carboline vs pyrazolopyrimidinone) with lower PDE6 cross-reactivity — useful for research protocols where visual pathway interference is a confound.
How Does Tadalafil Work?
PDE5 inhibition → cGMP accumulation → PKG activation → myosin light chain phosphatase activation → smooth muscle relaxation → vasodilation. In penile tissue: NO from non-adrenergic non-cholinergic (NANC) neurons activates guanylyl cyclase → cGMP → relaxation of cavernosal smooth muscle.
Tadalafil is a selective PDE5 inhibitor with the longest half-life of any approved PDE5 inhibitor (~17.5 hours). Structurally distinct from sildenafil (β-carboline vs pyrazolopyrimidinone) with lower PDE6 cross-reactivity — useful for research protocols where visual pathway interference is a confound.
How does Tadalafil work?
PDE5 inhibition → cGMP accumulation → PKG activation → myosin light chain phosphatase activation → smooth muscle relaxation → vasodilation. In penile tissue: NO from non-adrenergic non-cholinergic (NANC) neurons activates guanylyl cyclase → cGMP → relaxation of cavernosal smooth muscle.
QSC stocks research-grade Tadalafil at ≥99% HPLC purity with Janoshik COA verification. Available in Tablets, 5mg, 10mg, 20mg with 5-region domestic US and international shipping.
What compounds are related to Tadalafil?
Researchers studying Tadalafil frequently also investigate: Sildenafil, Vardenafil, PT-141.
Research Use Only: All QSC products are sold strictly for in vitro laboratory research. Not for human or veterinary use. Researchers are responsible for compliance with local regulations.
