What is Tryptomer 50mg (AMITRIPTYLINE)?
Tricyclic antidepressant widely used at low doses for neuropathic pain, fibromyalgia, migraine prevention, IBS, and insomnia. More effective at pain/sleep doses (10–50mg) than antidepressant doses.
How it Works
Inhibits serotonin and norepinephrine reuptake; blocks H1 (sedation), muscarinic, and alpha-1 receptors. Pain benefit relates to norepinephrine enhancement in descending pain inhibitory pathways.
Quick Specs
| Form | Oral tablets — pre-dosed |
| Active Ingredient | AMITRIPTYLINE |
| Dose per Tablet | 50MG |
| Pack Size | 105 tablets |
| Storage | Room temperature (15–25°C), cool dry place |
| Shelf Life | 2–3 years (properly stored) |
Common Side Effects
Sedation, dry mouth, constipation, urinary retention, blurred vision, weight gain, orthostatic hypotension, QT prolongation. Anticholinergic effects more pronounced in elderly.
Safety Warnings
⚠️ QT prolongation — potentially fatal with overdose. MAOIs absolutely contraindicated. Lowers seizure threshold. Narrow therapeutic index. Extreme caution in elderly (falls, confusion, urinary retention).
