What is Tadalafil?
Tadalafil (Cialis) is a selective PDE5 inhibitor with the longest half-life in its class (~17.5hr, duration up to 36hr). Prevents cGMP degradation in smooth muscle, sustaining NO-mediated vasodilation. FDA-approved for erectile dysfunction, BPH, and pulmonary arterial hypertension (PAH/Adcirca). CAS 171596-29-5.
Research Applications
NO/cGMP Pathway
PDE5 inhibition → sustained cGMP → smooth muscle relaxation
Pulmonary Hypertension
PAH vasodilation — Adcirca indication — pulmonary vascular resistance
Long-Duration Protocol
17.5hr half-life — chronic dosing and sustained inhibition studies
Cardiac Preload/Afterload
Venodilation and arterial effects — cardiac function modelling
vs PT-141 Pairing
Peripheral PDE5 (tadalafil) + central MC4R (PT-141) — erectile physiology
Quick Specs
| Form | Tablet — 20mg per tablet, 100-tablet bottle |
| CAS Number | 171596-29-5 |
| Molecular Formula | C₂₂H₁₉N₃O₄ |
| Molecular Weight | 389.4 g/mol |
| Compound Type | PDE5 Inhibitor |
| Purity | ≥99% by HPLC — every batch |
| Identity | MS molecular weight confirmed — every batch |
| COA | Janoshik-independent, publicly verifiable |
| Manufacture | In-house synthesis — Qingdao, China |
| Storage | Room temperature sealed | cool, dry storage |
| Shelf Life | 24 months unopened |
Certificate of Analysis (COA)
Frequently Asked Questions
🧪 Peptide Research Tools: Use QSC’s free peptide calculators — reconstitution, BAC water, dosing, half-life, and mixing charts.
🌍 Domestic shipping: 🇺🇸 USA 5–7 days
🌏 International shipping: 7–14 days
