QSC RESEARCH GRADE
≥99% HPLC PurityMS ConfirmedJanoshik COAIn-House SPPSChina Warehouse
What is Sildenafil?
Sildenafil Citrate is a potent, selective PDE5 (phosphodiesterase type 5) inhibitor. Blocks cGMP degradation, elevating intracellular cGMP and mediating smooth muscle relaxation via PKG activation. Standard PDE5 inhibitor reference compound for vascular biology, erectile physiology, pulmonary hypertension, and cGMP pathway research. Research use only.
Research Applications
PDE5 Inhibition Pharmacology
IC50, selectivity panel (PDE1–11), cGMP elevation kinetics — reference compound
Erectile Physiology Research
Corpus cavernosum smooth muscle relaxation, haemodynamic models, NO-cGMP amplification
Pulmonary Hypertension
Pulmonary vascular resistance, PDE5 expression in lung, vasorelaxation studies
Endothelial Function
NO pathway amplification, endothelial cGMP signalling, vascular tone modulation
PDE6 Cross-Reactivity
Sildenafil PDE6 inhibition — visual side effect mechanism, retinal photoreceptor research
Quick Specs
| Form | Raw bulk powder (crystalline/amorphous) |
| Purity | ≥99% by HPLC — every batch |
| CAS Number | 171599-83-0 |
| Molecular Formula | C28H38N6O11S, MW 666.7 |
| Identity | MS molecular weight confirmed — every batch |
| Compound Type | PDE5 Inhibitor |
| COA | Janoshik-independent, publicly verifiable |
| Manufacture | In-house synthesis — Qingdao, China |
| Storage | Room temperature sealed | cool, dry storage |
| Shelf Life | 24 months (unopened) |

