ARA-290 10mg | 10-Vial Kit | 100mg total | Cibinetide

🇺🇸 1-Region Domestic Shipping
QSC ARA-290 (Cibinetide) — innate repair receptor (IRR) agonist, EPO helix B peptide. ≥99% HPLC purity, MS confirmed, Janoshik COA. Research use only.

🌍 Domestic shipping: 🇺🇸 USA 5–7 days
🌏 International shipping: 7–14 days

$210

or
SKU: QSC-RA10-ARA290-10MG-10VIAL
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What is ARA-290?

ARA-290 (Cibinetide) is an 11-amino acid synthetic peptide derived from the helix B surface peptide (HBSP) of erythropoietin (EPO). Unlike EPO itself, ARA-290 selectively activates the innate repair receptor (IRR) — a heterodimeric complex of the EPO receptor and the beta common receptor (βcR) — without engaging the classical homodimeric EPO receptor responsible for erythropoiesis. This separation of tissue-protective signalling from haematopoietic activity makes ARA-290 a focused research tool for studying EPO’s non-erythroid cytoprotective and anti-inflammatory properties.

Research Applications

Mechanism of Action

ARA-290 binds the IRR (a heterodimer of EPO receptor subunit + βcR subunit), triggering a distinct intracellular signalling cascade from classical EPO. Downstream activates PI3K/Akt (cell survival), JAK2/STAT3 (anti-apoptotic gene expression), and MAPK/ERK (cell proliferation) pathways. Critically, does not activate the EPOR homodimer, so does not stimulate erythropoiesis, haemoglobin synthesis, or platelet aggregation risk associated with exogenous EPO administration.

Key Research Data

Phase 2 RCT (Sarcoidosis SFN) N=55; ARA-290 4mg SC × 28 days vs placebo. Primary endpoint: corneal nerve fibre density (CNFD). Result: significant CNFD preservation + pain NRS reduction (p<0.05)
Pancreatic islet study Human islets treated with IL-1β + IFN-γ; ARA-290 rescued GSIS, reduced apoptosis markers (caspase-3), reduced TNF-α secretion
Rodent ischaemia model ARA-290 SC pre-treatment reduced renal tubular injury scores 40-60% vs vehicle in I/R models (rat)
Selectivity vs EPO No haematopoietic effect confirmed across multiple studies: haematocrit, haemoglobin, reticulocyte count unchanged at research doses

Quick Specs

Compound ARA-290 (Cibinetide)
Sequence QEQLERALNSS (11 amino acids, helix B surface peptide of EPO)
Molecular Formula C₅₄H₈₈N₁₄O₁₉
Molecular Weight ~1,277.4 Da
CAS Number 866395-18-8
Format Lyophilised white powder
Vial content 10mg per vial
Purity ≥99% HPLC
Identity MS confirmed
Storage −20°C lyophilised; 4°C reconstituted, use within 7 days
Reconstitution Bacteriostatic water or 0.9% NaCl

Certificate of Analysis (COA)

Frequently Asked Questions

How do I reconstitute this peptide?
Add 1–2mL bacteriostatic water to the lyophilized vial by directing water down the inner wall of the vial. Swirl gently until the powder fully dissolves — do not shake or vortex. The solution should be clear and colourless. Use immediately or refrigerate at 2–8°C.
How should this peptide be stored?
Store lyophilized peptide vials at −20°C for long-term storage. Once reconstituted, store at 2–8°C (refrigerator) and use within 21–28 days. Avoid repeated freeze-thaw cycles, direct light, and heat exposure.
What purity is this QSC compound and how is it verified?
All QSC compounds are tested to ≥99% purity by HPLC peak area analysis on every production batch. Molecular identity is confirmed by mass spectrometry. A Certificate of Analysis (COA) is published on the product page and independently verifiable at verify.janoshik.com using the batch reference number.
🧪 Peptide Research Tools: Use QSC’s free peptide calculators — reconstitution, BAC water, dosing, half-life, and mixing charts.
🌍 Domestic shipping: 🇺🇸 USA 5–7 days
🌏 International shipping: 7–14 days

Source: PubMed / NCBI  ·  Last 10 years  ·  Refreshed every 24 hours  ·  For research reference only — not clinical guidance.

⚠️ RESEARCH USE ONLY — NOT FOR HUMAN CONSUMPTION

QSC products are strictly for in vitro and in vivo laboratory research. Not intended for diagnostic, therapeutic, or personal use.

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Research Use Disclaimer

All QSC products are strictly for laboratory, scientific, and research use only. They are not for human consumption, medical treatment, diagnosis, or disease prevention.

By purchasing or using QSC products, you confirm:

  • You are a qualified researcher or acting under the supervision of one.
  • Products will only be used for legitimate research purposes.
  • Products are not evaluated by the FDA or any regulatory authority for human use.
  • You assume all responsibility for legal compliance, proper handling, and storage.
  • You meet the legal age requirement in your jurisdiction.
No Warranty: Products are sold “as is,” with no express or implied warranties regarding efficacy, safety, or suitability. Results in research may vary. QSC is not responsible for outcomes, interpretations, or conclusions drawn from any studies conducted using these products.
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General Safety & Handling

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Not for Human Use

These compounds are for research only. Any off-label, personal, or clinical use is strictly outside the intended scope of supply.

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PPE Required

Always use appropriate personal protective equipment (gloves, lab coat, eye protection) when handling peptides.

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Storage Compliance

Follow product-specific storage conditions to maintain identity, purity, and biological activity.

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Proper Disposal

Dispose of all materials in accordance with institutional biosafety, chemical waste, and hazardous material protocols.

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Verify Quality

Janoshik COAs are available on every product page. Verify batch identity (MS confirmed) and purity (≥99% HPLC) before use.

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Peptide Storage Guidelines

🌑 Light-protected💧 Low moisture🌡️ Stable temperature🔬 Sterile handling

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