Selank potentiates GABA-A receptor activity β anxiolytic effect without benzodiazepine receptor binding β no physical dependence potential in research models
Modulates IL-6, IFN-Ξ³, and BDNF β immune-cognitive crosstalk research application beyond pure anxiolytic activity
Research Questions Answered
What is Selank?
Selank (TKPRPGP) is a synthetic heptapeptide anxiolytic nootropic developed at the Institute of Molecular Genetics (Moscow). It is the stable analogue of the naturally occurring tetrapeptide tuftsin (TKPR) with a Pro-Gly-Pro extension that increases stability. Selank is approved in Russia for anxiety and asthenia. It works via GABA-A potentiation (without benzodiazepine receptor binding), enkephalinase inhibition, and immune modulation β producing an anxiolytic effect with a different safety/dependence profile than benzodiazepines.
How does Selank work?
Selank works through three mechanisms: (1) GABA-A modulation β potentiates GABA-A receptor without binding benzodiazepine sites, reducing anxiety without direct BDZ dependence risk; (2) Enkephalin stability β inhibits enzymes that degrade endogenous enkephalins (endorphins), extending their half-life and producing anxiolytic/analgesic effects; (3) Immune modulation β regulates IL-6, IFN-Ξ³, and BDNF, which has cognitive research implications beyond anxiolysis.
What is the difference between Selank and Semax?
Selank: GABA-A anxiolytic, calming, anti-anxiety, immune modulation. Semax: MC4R stimulatory, BDNF upregulation, cognitive enhancement. Different mechanisms and research endpoints. Together they are complementary CNS research peptides β Semax for cognitive stimulation, Selank for anxiety/stress. Often studied in combination for full CNS biology coverage.
What is Selank used for in research?
Selank research applications: anxiety models (generalised anxiety, stress-induced anxiety, social anxiety), GABA-A pharmacology (non-benzodiazepine GABAergic modulation), enkephalin system research, immune-cognitive crosstalk (IL-6/IFN-Ξ³ modulation), comparative anxiolytic research (Selank vs benzodiazepines, vs Afobazole), memory and learning models (Selank has nootropic effects alongside anxiolytic).
Where can I buy Selank for research?
Research-grade Selank is available from QSC (qscpeptide.com) at β₯99% HPLC purity with Janoshik COA. US Domestic Warehouse: 2β4 business days. Research use only.
Is Selank approved?
Selank is approved in Russia (Pharmsynthez) for anxiety and asthenic conditions. Not FDA approved. Research-grade Selank from QSC is sold for in vitro laboratory research only.
What is Selank dose in research?
Russian clinical protocols: 400β900 mcg intranasally per dose. Animal research: 0.1β1 mg/kg. In vitro research: dose-response per published literature.
What is the Selank half-life?
Selank has a short half-life in serum (~1β2 minutes for the parent peptide) but its enkephalinase-inhibiting effect extends its biological activity window. The Pro-Gly-Pro extension improves stability vs tuftsin alone.
How does Selank compare to benzodiazepines?
Selank produces GABA-A potentiation without binding benzodiazepine sites β research models show anxiolytic effect without the sedation, muscle relaxation, or dependence/withdrawal profile of BDZs. This makes Selank a research tool for studying GABAergic anxiolysis without benzodiazepine receptor confounds.
How is Selank stored?
Lyophilised Selank: store at β20Β°C. Reconstituted: 4Β°C, use within 28 days. Selank is relatively stable for a heptapeptide due to its Pro-Gly-Pro C-terminal extension.
Where to Buy Research-Grade Selank
β₯99% HPLC Β· Janoshik COA Β· US Domestic 2β4 Days Β· Research Use Only
