RAD-140 (Testolone): What It Is, How It Works & Research Data | QSC
QSC RESEARCH COMPOUND
RAD-140 (Testolone)
High-affinity SARM in Phase 2 oncology trials for AR+/ER+ breast cancer.
≥99% HPLC Purity MS Confirmed Janoshik COA Research Use Only
What is RAD-140 (Testolone)?
RAD-140 is a non-steroidal full AR agonist with the highest binding affinity of any studied SARM (Ki ~7nM) — higher than testosterone itself at the androgen receptor. Uniquely, RAD-140 has entered Phase 2 clinical trials (ARTEST trial) as an AR agonist for AR+/ER+ breast cancer, where AR activation suppresses ER-driven proliferation.
How Does RAD-140 (Testolone) Work?
Full AR agonism with brain/muscle selectivity: AR activation in hippocampal neurons produces neuroprotective effects (activation of pro-survival MAPK/CREB pathways) while maintaining reduced prostate stimulation. In AR+/ER+ breast cancer: AR agonism competitively inhibits ER signalling in ER-dependent cell lines.
Key Research
ARTEST Phase 2 trial (Lim et al., 2022): RAD-140 in metastatic AR+/ER+ breast cancer showed disease control in 10/12 evaluable patients and 8-month median progression-free survival. Establishes first oncological clinical proof-of-concept for a SARM.
RAD-140 is a non-steroidal full AR agonist with the highest binding affinity of any studied SARM (Ki ~7nM) — higher than testosterone itself at the androgen receptor. Uniquely, RAD-140 has entered Phase 2 clinical trials (ARTEST trial) as an AR agonist for AR+/ER+ breast cancer, where AR activation suppresses ER-driven proliferation.
How does RAD-140 (Testolone) work?
Full AR agonism with brain/muscle selectivity: AR activation in hippocampal neurons produces neuroprotective effects (activation of pro-survival MAPK/CREB pathways) while maintaining reduced prostate stimulation. In AR+/ER+ breast cancer: AR agonism competitively inhibits ER signalling in ER-dependent cell lines.
What research has been done on RAD-140 (Testolone)?
ARTEST Phase 2 trial (Lim et al., 2022): RAD-140 in metastatic AR+/ER+ breast cancer showed disease control in 10/12 evaluable patients and 8-month median progression-free survival. Establishes first oncological clinical proof-of-concept for a SARM.
Where can I buy research-grade RAD-140 (Testolone)?
QSC stocks research-grade RAD-140 (Testolone) at ≥99% HPLC purity with Janoshik COA verification. Available in Oral capsules/tablets, 10mg with 5-region domestic US and international shipping.
What compounds are related to RAD-140 (Testolone)?
Research Use Only: All QSC products are sold strictly for in vitro laboratory research. Not for human or veterinary use. Researchers are responsible for compliance with local regulations.
