PT-141 (Bremelanotide): What It Is, How It Works & Research Data | QSC
QSC RESEARCH COMPOUND
PT-141 (Bremelanotide)
Melanocortin receptor agonist studied for central sexual function pathways.
≥99% HPLC Purity MS Confirmed Janoshik COA Research Use Only
What is PT-141 (Bremelanotide)?
PT-141 (Bremelanotide) is a cyclic heptapeptide and non-selective melanocortin receptor agonist with activity at MC3R and MC4R in the central nervous system. Unlike PDE5 inhibitors which act peripherally via vascular mechanisms, PT-141 acts centrally on hypothalamic melanocortin pathways.
How Does PT-141 (Bremelanotide) Work?
MC4R agonism in the medial preoptic area (MPOA) and paraventricular nucleus activates dopaminergic pathways associated with sexual motivation and arousal. MC3R activity modulates feeding behaviour and energy homeostasis. Central action explains efficacy in models where peripheral vasodilation is not the limiting factor.
Key Research
Phase 3 (Vyleesi approval): PT-141 1.75mg subcutaneous showed statistically significant improvement in sexual desire and distress scores in hypoactive sexual desire disorder (HSDD) in premenopausal women — the basis for FDA approval. Research compound version for laboratory use.
PT-141 (Bremelanotide) is a cyclic heptapeptide and non-selective melanocortin receptor agonist with activity at MC3R and MC4R in the central nervous system. Unlike PDE5 inhibitors which act peripherally via vascular mechanisms, PT-141 acts centrally on hypothalamic melanocortin pathways.
How does PT-141 (Bremelanotide) work?
MC4R agonism in the medial preoptic area (MPOA) and paraventricular nucleus activates dopaminergic pathways associated with sexual motivation and arousal. MC3R activity modulates feeding behaviour and energy homeostasis. Central action explains efficacy in models where peripheral vasodilation is not the limiting factor.
What research has been done on PT-141 (Bremelanotide)?
Phase 3 (Vyleesi approval): PT-141 1.75mg subcutaneous showed statistically significant improvement in sexual desire and distress scores in hypoactive sexual desire disorder (HSDD) in premenopausal women — the basis for FDA approval. Research compound version for laboratory use.
Where can I buy research-grade PT-141 (Bremelanotide)?
QSC stocks research-grade PT-141 (Bremelanotide) at ≥99% HPLC purity with Janoshik COA verification. Available in Lyophilised powder, 10mg vial kits with 5-region domestic US and international shipping.
What compounds are related to PT-141 (Bremelanotide)?
Researchers studying PT-141 (Bremelanotide) frequently also investigate: Melanotan II, Melanotan I, Kisspeptin-10.
Research Use Only: All QSC products are sold strictly for in vitro laboratory research. Not for human or veterinary use. Researchers are responsible for compliance with local regulations.
