Peptides for Sexual Health Research | PT-141, PDE5, HPG Axis | QSC Peptides
QSC RESEARCH COMPOUND GUIDE
MC3R/MC4RPT-141CentralHypothalamic mPOA
Sexual health research spans central melanocortin (hypothalamic), peripheral vascular (PDE5/NO/cGMP), hormonal (HPG axis), and neuropeptide mechanisms. QSC supplies compounds across all these axes — enabling mechanistic dissection of central vs peripheral sexual physiology.
What is the difference between PT-141 and PDE5 inhibitors for sexual function research?
PT-141 acts centrally — it activates MC3R/MC4R in the hypothalamic mPOA, driving dopamine release and central sexual arousal without peripheral vascular effects. PDE5 inhibitors (tadalafil, vardenafil) act peripherally — preventing cGMP breakdown in penile smooth muscle → sustained vasodilation. Combining both allows dissection of central vs peripheral contributions to erectile function.
Why is kisspeptin-10 relevant to sexual health research?
Kisspeptin-10 activates GPR54 on GnRH neurons → GnRH pulse → LH/FSH release → gonadal testosterone/oestradiol production. It is the master regulator of HPG axis activation and the research tool for studying puberty onset, HPG axis gating, and GnRH pulse dynamics. In sexual health, it addresses the hormonal input to libido via gonadal steroid production.
What is the research value of studying PT-141 + tadalafil together?
PT-141 (central) + tadalafil (peripheral) allows isolation of the relative contribution of central arousal vs peripheral vasodilation to erectile function. With MC3R/MC4R antagonists, researchers can further determine which melanocortin receptor mediates PT-141 effects. This dissection is not possible with either compound alone.
What formats does QSC supply sexual health research compounds in?
Lyophilised research vials (peptides), tablet research kits (PDE5 inhibitors), injectable solutions (androgens). ≥99% HPLC purity, Janoshik COA. Ships domestically in USA, EU, UK, Canada, Australia.
