≥99% HPLC Purity MS Confirmed Janoshik COA In-House SPPS 8-Region Worldwide Shipping
Compound type: PEGylated IGF-1 Ec Splice Variant — Extended Half-Life MGF CAS Number: Not assigned
What is PEG-MGF?
PEG-MGF (polyethylene glycol conjugated Mechano Growth Factor) addresses the primary limitation of native MGF — its minute-scale half-life in vivo. PEGylation of the E-domain peptide extends half-life from minutes to days, enabling systemic rather than purely local delivery in research models. The PEG moiety reduces renal clearance and proteolytic degradation without significantly impacting IGF-1 receptor binding or satellite cell activation. PEG-MGF enables once-weekly or longer dosing intervals in animal models, making it the practical research tool for extended MGF pathway studies where native MGF’s instability is prohibitive.
Research Applications
Extended MGF Pharmacokinetics
PEGylation extends half-life from minutes to days — weekly dosing in animal models
Systemic vs. Local MGF
Distinguishes systemic MGF effects from purely autocrine/paracrine native MGF
Satellite Cell Research
Sustained satellite cell activation without repeated daily injections
Muscle Hypertrophy
Anabolic research model with practical dosing intervals
Comparison with Native MGF
PK comparison — onset, Cmax, and duration of satellite cell activation
Native MGF has a half-life of minutes, requiring very frequent dosing and limiting systemic delivery. PEGylation extends half-life to days, enabling practical research protocols with once-weekly or less-frequent administration. PEG-MGF also allows systemic distribution vs. the purely local paracrine activity of native MGF.
How is PEG-MGF reconstituted?
Add 1–2mL bacteriostatic water to the lyophilized vial. PEG-MGF dissolves readily. Swirl gently — do not shake. Store reconstituted at 2–8°C for up to 21 days. The PEGylation significantly improves aqueous stability vs. native MGF.
What purity is QSC PEG-MGF?
QSC PEG-MGF is ≥99% HPLC pure with MS-confirmed PEGylated E-domain identity on every batch. COA verifiable at verify.janoshik.com.
Research Use Only: All QSC compounds are sold strictly for laboratory research purposes only. Not for human consumption, veterinary use, or any other application. Researchers are responsible for compliance with local regulations.
QSC Network
Compound reference, COA verification, and regional warehouse information across the QSC network.
