Mechano Growth Factor (MGF) is a splice variant of IGF-1 generated by alternative splicing to include the E peptide domain from exon 5 (Ec in humans). Unlike systemic IGF-1-Ea, MGF is locally expressed in response to mechanical loading — acting as an autocrine/paracrine signal for satellite cell (muscle stem cell) activation and proliferation. The E-domain peptide is the active component, binding non-IGF-1R targets to drive satellite cell pool expansion independently of systemic IGF-1 pathways. MGF expression is highest immediately post-exercise and declines rapidly — motivating PEG-MGF development for extended half-life research.
Research Applications
Satellite Cell Activation
Muscle stem cell pool expansion via local IGF-1 Ec E-domain signalling
Mechanical Loading Research
Load-induced muscle repair signal characterisation — post-exercise biology
Muscle Hypertrophy Models
Autocrine/paracrine complement to systemic IGF-1-Ea in anabolic research
Comparison with PEG-MGF
Short-acting native vs. long-acting PEGylated pharmacokinetic comparison
Tendon and Ligament
E-domain signalling in connective tissue repair alongside BPC-157/TB-500
MGF is an IGF-1 splice variant produced locally in muscle in response to mechanical loading. Unlike systemic IGF-1 which circulates long-term, MGF acts as a rapid autocrine/paracrine satellite cell activator — it drives muscle stem cell proliferation independently of IGF-1 receptor pathways. Its extremely short half-life (minutes) motivated development of PEG-MGF.
How is MGF reconstituted?
Add 1–2mL bacteriostatic water to the lyophilized MGF vial. MGF dissolves readily to a clear colourless solution. Note: native MGF has a very short half-life in aqueous solution — use shortly after reconstitution. Store at 2–8°C for up to 14 days.
What purity is QSC MGF?
QSC MGF is ≥99% HPLC pure with MS-confirmed E-domain peptide identity on every batch. COA verifiable at verify.janoshik.com.
Research Use Only: All QSC compounds are sold strictly for laboratory research purposes only. Not for human consumption, veterinary use, or any other application. Researchers are responsible for compliance with local regulations.
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