LGD-4033 (Ligandrol): What It Is, How It Works & Research Data | QSC
QSC RESEARCH COMPOUND
LGD-4033 (Ligandrol)
Non-steroidal SARM studied for muscle wasting and androgen receptor selectivity.
≥99% HPLC Purity MS Confirmed Janoshik COA Research Use Only
What is LGD-4033 (Ligandrol)?
LGD-4033 is a non-steroidal full AR agonist with the highest binding affinity among validated SARMs (Ki ~1nM). Designed for tissue selectivity: full anabolic agonism in muscle and bone with reduced androgenic activity in prostate and seminal vesicles due to differential co-activator recruitment.
How Does LGD-4033 (Ligandrol) Work?
AR full agonism in muscle → AR-RE gene transcription → IGF-1, follistatin, and structural protein upregulation → satellite cell activation and protein synthesis. In prostate: same AR binding but different co-activator complex → reduced transcriptional output for androgenic genes (tissue selectivity mechanism).
Key Research
Phase 2 RCT (Basaria et al., Lancet, 2010): LGD-4033 0.3mg–1mg daily for 21 days in healthy males produced dose-dependent lean mass gains (+1.1kg at 1mg), dose-dependent testosterone suppression, and no prostate-specific antigen changes.
LGD-4033 is a non-steroidal full AR agonist with the highest binding affinity among validated SARMs (Ki ~1nM). Designed for tissue selectivity: full anabolic agonism in muscle and bone with reduced androgenic activity in prostate and seminal vesicles due to differential co-activator recruitment.
How does LGD-4033 (Ligandrol) work?
AR full agonism in muscle → AR-RE gene transcription → IGF-1, follistatin, and structural protein upregulation → satellite cell activation and protein synthesis. In prostate: same AR binding but different co-activator complex → reduced transcriptional output for androgenic genes (tissue selectivity mechanism).
What research has been done on LGD-4033 (Ligandrol)?
Phase 2 RCT (Basaria et al., Lancet, 2010): LGD-4033 0.3mg–1mg daily for 21 days in healthy males produced dose-dependent lean mass gains (+1.1kg at 1mg), dose-dependent testosterone suppression, and no prostate-specific antigen changes.
Where can I buy research-grade LGD-4033 (Ligandrol)?
QSC stocks research-grade LGD-4033 (Ligandrol) at ≥99% HPLC purity with Janoshik COA verification. Available in Oral capsules/tablets, 10mg with 5-region domestic US and international shipping.
What compounds are related to LGD-4033 (Ligandrol)?
Research Use Only: All QSC products are sold strictly for in vitro laboratory research. Not for human or veterinary use. Researchers are responsible for compliance with local regulations.
