Ipamorelin: What It Is, How It Works & Research Data | QSC
QSC RESEARCH COMPOUND
Ipamorelin
Selective GHSR-1a agonist — cleanest GH secretagogue in research.
≥99% HPLC Purity MS Confirmed Janoshik COA Research Use Only
What is Ipamorelin?
Ipamorelin is a pentapeptide (Aib-His-D-2Nal-D-Phe-Lys-NH2) and selective ghrelin receptor (GHSR-1a) agonist. Unique selectivity profile: stimulates GH release without elevating cortisol, prolactin, or ACTH at research doses — making it the most pharmacologically clean GHRP for isolated GH axis research.
How Does Ipamorelin Work?
GHSR-1a agonism → Gαq/PKC pathway → IP3 and DAG → Ca²⁺ mobilisation → GH granule exocytosis from somatotrophs. Does not activate ACTH/cortisol axis at selective doses, unlike GHRP-6.
Key Research
Comparative selectivity data vs GHRP-2/6: ipamorelin produces equivalent GH pulse amplitude with significantly lower cortisol/ACTH elevation. Frequently used as reference GHRP for GH axis research where cortisol interference is a confound.
Ipamorelin is a pentapeptide (Aib-His-D-2Nal-D-Phe-Lys-NH2) and selective ghrelin receptor (GHSR-1a) agonist. Unique selectivity profile: stimulates GH release without elevating cortisol, prolactin, or ACTH at research doses — making it the most pharmacologically clean GHRP for isolated GH axis research.
How does Ipamorelin work?
GHSR-1a agonism → Gαq/PKC pathway → IP3 and DAG → Ca²⁺ mobilisation → GH granule exocytosis from somatotrophs. Does not activate ACTH/cortisol axis at selective doses, unlike GHRP-6.
What research has been done on Ipamorelin?
Comparative selectivity data vs GHRP-2/6: ipamorelin produces equivalent GH pulse amplitude with significantly lower cortisol/ACTH elevation. Frequently used as reference GHRP for GH axis research where cortisol interference is a confound.
Where can I buy research-grade Ipamorelin?
QSC stocks research-grade Ipamorelin at ≥99% HPLC purity with Janoshik COA verification. Available in Lyophilised powder, 2mg and 5mg vial kits with 5-region domestic US and international shipping.
Research Use Only: All QSC products are sold strictly for in vitro laboratory research. Not for human or veterinary use. Researchers are responsible for compliance with local regulations.
