Estradiol Cypionate (E2C) is the most potent endogenous oestrogen (17β-estradiol) esterified with cypionate for extended release (~14-day half-life). Estradiol binds ERα and ERβ with high affinity to drive genomic transcription of oestrogen-responsive genes. ERα mediates classic reproductive, cardiovascular, and bone effects; ERβ modulates CNS, immune, and anti-proliferative activity. Long-acting injectable form enables sustained, stable oestrogen levels for HRT research, transgender healthcare models, and comparative ER pharmacology — contrasting the short half-life of unconjugated oestradiol.
Research Applications
ERα/ERβ Pharmacology
High-affinity endogenous oestrogen for ER receptor characterisation
HPG Axis Modulation
Oestrogen-mediated LH/FSH suppression and kisspeptin pathway research
Bone Density
ERα-mediated osteoclast suppression and bone mineral density research
Cardiovascular
Oestrogen-mediated lipid profile and endothelial function research
Comparative HRT
Long-acting oestrogen depot for HRT pharmacokinetic modelling
Estradiol Cypionate is 17β-estradiol esterified with cypionate for ~14-day injectable half-life. It is the most potent endogenous oestrogen, binding ERα and ERβ to regulate reproductive, cardiovascular, bone, CNS, and immune functions. Used in research for ER pharmacology, HPG axis oestrogen effects, bone density, and long-acting HRT pharmacokinetic modelling.
How is Estradiol Cypionate supplied?
QSC Estradiol Cypionate is supplied as a ready-to-use oil-based injectable solution. No reconstitution required. Store at room temperature away from direct sunlight.
What purity is QSC Estradiol Cypionate?
QSC Estradiol Cypionate is ≥99% HPLC pure with MS-confirmed identity on every batch. COA verifiable at verify.janoshik.com.
Research Use Only: All QSC compounds are sold strictly for laboratory research purposes only. Not for human consumption, veterinary use, or any other application. Researchers are responsible for compliance with local regulations.
QSC Network
Compound reference, COA verification, and regional warehouse information across the QSC network.
