As a short peptide, epitalon penetrates nuclei and modulates chromatin structure → gene expression changes in longevity-associated pathways
PINEAL REGULATION
Targets pineal gland biology → melatonin synthesis regulation → circadian rhythm support → downstream antioxidant and anti-ageing effects
Research Questions Answered
What is Epitalon?
Epitalon (also spelled Epithalon) is a synthetic tetrapeptide (Ala-Glu-Asp-Gly, 4 amino acids) developed by Prof. Vladimir Khavinson at the St. Petersburg Institute of Bioregulation and Gerontology. It is the synthetic analogue of Epithalamin — a natural polypeptide extract from the bovine pineal gland. Epitalon is the most studied short peptide bioregulator, with research demonstrating telomerase activation, life-span extension in animal models, and circadian/melatonin regulation.
How does Epitalon work?
Epitalon works via three mechanisms: (1) Telomerase activation — Epitalon induces expression of hTERT (the catalytic subunit of telomerase) in somatic cells, extending telomere length and delaying replicative senescence; (2) Chromatin remodelling — as a short nuclear-penetrating peptide, it modulates chromatin structure affecting gene expression; (3) Pineal regulation — targets pineal gland biology, supporting melatonin synthesis and circadian rhythm. These mechanisms make epitalon the benchmark peptide for telomere and longevity biology research.
What is Epitalon used for in research?
Epitalon research applications: telomere biology (hTERT activation, telomere length measurement), longevity models (lifespan extension data in mice, rats, and Drosophila), pineal biology and melatonin research, circadian rhythm studies, antioxidant research (epitalon increases superoxide dismutase activity), oncology research (tumour-suppressive effects in some models), and comparative longevity research alongside FOXO4-DRI, NAD+, and MOTS-c.
What is the difference between Epitalon and Pinealon?
Both are Khavinson peptide bioregulators from the St. Petersburg school. Epitalon (4 AA: Ala-Glu-Asp-Gly): focuses on telomerase activation and pineal biology. Pinealon (3 AA: Glu-Asp-Arg): focuses on chromatin-based gene expression modulation with more CNS/neuroprotection emphasis. Epitalon has more published research data. They are frequently used together in longevity research stacks.
Where can I buy Epitalon for research?
Research-grade Epitalon is available from QSC (qscpeptide.com) at ≥99% HPLC purity with Janoshik COA (verify.janoshik.com). US Domestic Warehouse: 2–4 business day delivery. All products sold strictly for in vitro laboratory research only.
Does Epitalon extend lifespan?
Animal model data: Epitalon extended mean lifespan in mice (by ~25%) and rats in studies by the Khavinson group. Drosophila data shows 11–16% lifespan extension. Human data is limited to observational and small clinical series — no randomised controlled human lifespan trial exists. The animal model mechanism data is robust, making epitalon a key research tool in longevity biology even absent human RCT data.
What is the Epitalon dose in research?
Published animal research used 0.5–1 mg/kg in most protocols. Human observational research from the Khavinson group used 5–10mg in various regimens. For in vitro research, dose-response protocols should reference compound-specific published literature. QSC provides reconstitution guidance with all Epitalon orders.
What is Epitalon storage?
Lyophilised Epitalon: store at −20°C. Reconstituted: store at 4°C, use within 28 days. Reconstitute with bacteriostatic water. As a 4-AA tetrapeptide, Epitalon is quite stable compared to larger peptides — it has excellent thermal stability and retains activity well in aqueous solution.
Is Epitalon the same as Epithalamin?
No — Epithalamin is a natural polypeptide extract from bovine pineal gland (the parent compound that led to epitalon’s discovery). Epitalon is the synthetic, defined tetrapeptide (Ala-Glu-Asp-Gly) created by the Khavinson group as the active component of Epithalamin. Epitalon has a defined sequence, known molecular weight (390.35 Da), and is reproducible by SPPS — making it the research standard over the natural extract.
How does Epitalon compare to FOXO4-DRI for longevity research?
Different mechanisms: Epitalon targets telomerase activation — preventing telomere shortening and replicative senescence. FOXO4-DRI is a senolytic — it selectively eliminates already-senescent cells by disrupting the FOXO4-p53 interaction. Complementary in longevity research: Epitalon slows the process leading to senescence; FOXO4-DRI clears cells that have already become senescent. Often researched together for comprehensive longevity biology.
Where to Buy Research-Grade Epitalon
≥99% HPLC · Janoshik COA · US Domestic 2–4 Days · Research Use Only
