CJC-1295 No-DAC vs Sermorelin | GHRH Analogue Research Comparison | QSC
CJC-1295 No-DAC vs Sermorelin — GHRH Analogue Comparison
CJC-1295 No-DAC and Sermorelin are both GHRH analogues that stimulate pituitary GH release — but with different sequence length, half-life, and binding characteristics. This comparison covers the key differences for researchers designing GH pulse and IGF-1 axis studies.
Side-by-Side Comparison
Property
CJC-1295 No-DAC
Sermorelin
Full name
CJC-1295 without DAC
Sermorelin (GHRH 1-29)
CAS
863288-34-0
86168-78-7
Sequence length
30 amino acids (modified GHRH)
29 amino acids (GHRH 1-29 natural sequence)
Half-life
~30 minutes
~10-20 minutes
GHRH receptor
Full agonist — modified GHRH 1-29 with modifications at position 2,8,15,27
Full agonist — natural GHRH 1-29 sequence
GH pulse effect
Amplifies pulse amplitude — pulsatile, not sustained
Amplifies pulse amplitude — very short-acting, pulsatile
Bioavailability
Slightly improved vs sermorelin due to modification
Pairs with GHRP-2/6/ipamorelin for GH axis research
QSC purity
≥99% HPLC — Janoshik COA
≥99% HPLC — Janoshik COA
CJC-1295 No-DAC vs CJC-1295 with DAC — important distinction
CJC-1295 No-DAC (this comparison) is pulsatile — short half-life, natural GH pulse pattern. CJC-1295 with DAC (drug affinity complex) uses maleimidoproprionic acid to bind serum albumin and extends half-life to 6-8 days — producing sustained GH elevation. No-DAC preserves physiological pulsatility; with-DAC eliminates it. For most GH axis research, No-DAC is preferred because sustained GH elevation can cause GH receptor downregulation.
GHRH/GHRP synergy — why both receptor types are needed
GHRH (CJC-1295/sermorelin) and GHRP (ipamorelin/GHRP-2/GHRP-6) act on different receptors and their effects are synergistic. GHRH increases GH pulse amplitude; GHRP increases GH pulse frequency and works through ghrelin receptor (GHSR1a). The combination produces 3-10× greater GH release than either alone. For maximum GH axis stimulation in research, the GHRH/GHRP combination is the standard approach.
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Frequently Asked Questions
What is the primary difference between CJC-1295 No-DAC and sermorelin?
CJC-1295 No-DAC has amino acid modifications at positions 2, 8, 15, and 27 that improve stability against DPP-IV cleavage — extending its half-life slightly vs sermorelin. Sermorelin is the natural GHRH 1-29 sequence and the reference/baseline compound. In most GH pulse research, both produce similar GH pulse amplification with comparable duration.
Which GHRH analogue is better for in vivo research?
For most GH axis studies, CJC-1295 No-DAC and sermorelin are functionally similar. CJC-1295 No-DAC is slightly more stable. For baseline/reference studies using the natural GHRH sequence, sermorelin is preferred. For maximum GH pulse in combination with GHRPs, either works equivalently.
What is the best GHRP to pair with CJC-1295 No-DAC?
Ipamorelin is the preferred GHRP for most research — it produces significant GH release with minimal effects on cortisol, prolactin, or appetite. GHRP-2 is more potent. GHRP-6 stimulates appetite (via ghrelin axis). The choice depends on whether appetite or cortisol effects are experimental confounds.
