Cagrilintide: What It Is, How It Works & Research Data | QSC
QSC RESEARCH COMPOUND
Cagrilintide
Long-acting amylin analog studied in combination with semaglutide for weight research.
≥99% HPLC Purity MS Confirmed Janoshik COA Research Use Only
What is Cagrilintide?
Cagrilintide is a long-acting amylin analog (modified to extend half-life via fatty acid modification) that activates amylin receptors (AMY1/2/3 — calcitonin receptor + RAMP heteromers) in the area postrema and hypothalamus. Developed specifically for combination with semaglutide in the REDEFINE trial programme.
How Does Cagrilintide Work?
Amylin receptor activation in the area postrema → satiation signalling → reduced meal size. Complementary but distinct from GLP-1R: amylin reduces meal size, GLP-1R reduces appetite between meals. Combination (CagriSema) targets both mechanisms simultaneously for additive efficacy.
Key Research
REDEFINE-1 Phase 3: cagrilintide 2.4mg + semaglutide 2.4mg (CagriSema) produced −22.7% weight reduction at 68 weeks — significantly superior to either compound alone. Establishes amylin + GLP-1R combination as next-generation approach.
Cagrilintide is a long-acting amylin analog (modified to extend half-life via fatty acid modification) that activates amylin receptors (AMY1/2/3 — calcitonin receptor + RAMP heteromers) in the area postrema and hypothalamus. Developed specifically for combination with semaglutide in the REDEFINE trial programme.
How does Cagrilintide work?
Amylin receptor activation in the area postrema → satiation signalling → reduced meal size. Complementary but distinct from GLP-1R: amylin reduces meal size, GLP-1R reduces appetite between meals. Combination (CagriSema) targets both mechanisms simultaneously for additive efficacy.
What research has been done on Cagrilintide?
REDEFINE-1 Phase 3: cagrilintide 2.4mg + semaglutide 2.4mg (CagriSema) produced −22.7% weight reduction at 68 weeks — significantly superior to either compound alone. Establishes amylin + GLP-1R combination as next-generation approach.
Where can I buy research-grade Cagrilintide?
QSC stocks research-grade Cagrilintide at ≥99% HPLC purity with Janoshik COA verification. Available in Lyophilised powder, 10mg vial kits with 5-region domestic US and international shipping.
What compounds are related to Cagrilintide?
Researchers studying Cagrilintide frequently also investigate: Semaglutide, Retatrutide, Tirzepatide, Liraglutide.
Research Use Only: All QSC products are sold strictly for in vitro laboratory research. Not for human or veterinary use. Researchers are responsible for compliance with local regulations.
