Arimidex (Anastrozole): What It Is, How It Works & Research Data | QSC
QSC RESEARCH COMPOUND
Arimidex (Anastrozole)
Non-steroidal aromatase inhibitor studied for oestrogen suppression and androgen/oestrogen ratio research.
≥99% HPLC Purity MS Confirmed Janoshik COA Research Use Only
What is Arimidex (Anastrozole)?
Anastrozole is a triazole-based non-steroidal aromatase inhibitor that reversibly and competitively inhibits CYP19A1 (aromatase) — the enzyme converting androgens (testosterone, androstenedione) to oestrogens (oestradiol, oestrone). At 1mg/day, anastrozole suppresses plasma oestradiol by approximately 85%.
How Does Arimidex (Anastrozole) Work?
Competitive inhibition of CYP19A1 active site → blockade of androstenedione → oestrone and testosterone → oestradiol conversion → systemic oestrogen suppression. Unlike steroidal AIs (exemestane), anastrozole inhibition is reversible — aromatase activity returns after clearance.
Key Research
ATAC Phase 3 trial (n=9,366): anastrozole superior to tamoxifen for postmenopausal ER+ breast cancer — lower recurrence rate and contralateral breast cancer incidence. Multiple Phase 3 datasets establish oestrogen suppression kinetics and recovery profiles.
Related Compounds
Researchers studying Arimidex (Anastrozole) frequently also investigate: Exemestane, Letrozole, Tamoxifen, Testosterone Cypionate. View the complete QSC Research Manual →
Frequently Asked Questions
What is Arimidex (Anastrozole)?
Anastrozole is a triazole-based non-steroidal aromatase inhibitor that reversibly and competitively inhibits CYP19A1 (aromatase) — the enzyme converting androgens (testosterone, androstenedione) to oestrogens (oestradiol, oestrone). At 1mg/day, anastrozole suppresses plasma oestradiol by approximately 85%.
How does Arimidex (Anastrozole) work?
Competitive inhibition of CYP19A1 active site → blockade of androstenedione → oestrone and testosterone → oestradiol conversion → systemic oestrogen suppression. Unlike steroidal AIs (exemestane), anastrozole inhibition is reversible — aromatase activity returns after clearance.
What research has been done on Arimidex (Anastrozole)?
ATAC Phase 3 trial (n=9,366): anastrozole superior to tamoxifen for postmenopausal ER+ breast cancer — lower recurrence rate and contralateral breast cancer incidence. Multiple Phase 3 datasets establish oestrogen suppression kinetics and recovery profiles.
Where can I buy research-grade Arimidex (Anastrozole)?
QSC stocks research-grade Arimidex (Anastrozole) at ≥99% HPLC purity with Janoshik COA verification. Available in Tablets, 1mg with 5-region domestic US and international shipping.
What compounds are related to Arimidex (Anastrozole)?
Research Use Only: All QSC products are sold strictly for in vitro laboratory research. Not for human or veterinary use. Researchers are responsible for compliance with local regulations.
