Gonadorelin is native GnRH (Gonadotropin-Releasing Hormone), a 10-amino acid decapeptide (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH₂) secreted in pulses from hypothalamic GnRH neurons. It binds GnRH receptor (GnRHR) on pituitary gonadotrophs to stimulate pulsatile LH and FSH secretion — the HPG axis master regulator upstream of all gonadal steroid production. Continuous (non-pulsatile) GnRH exposure paradoxically suppresses LH/FSH via GnRHR downregulation — the basis of GnRH agonist therapy. Gonadorelin is used to test pituitary reserve, study GnRH pulse dynamics, and drive testosterone restoration in hypogonadism models.
Gonadorelin is native GnRH — the hypothalamic decapeptide that drives pulsatile LH and FSH secretion from pituitary gonadotrophs. It is used to test pituitary responsiveness, study HPG axis dynamics, drive testosterone restoration via LH stimulation, and investigate the pulsatile vs. continuous GnRH exposure paradox.
How is Gonadorelin reconstituted?
Add 1–2mL bacteriostatic water to the lyophilized vial. Gonadorelin dissolves readily as a small decapeptide. Swirl gently to a clear solution. Store at 2–8°C for up to 21 days.
What purity is QSC Gonadorelin?
QSC Gonadorelin is ≥99% HPLC pure with MS-confirmed decapeptide sequence on every batch. COA verifiable at verify.janoshik.com.
Research Use Only: All QSC compounds are sold strictly for laboratory research purposes only. Not for human consumption, veterinary use, or any other application. Researchers are responsible for compliance with local regulations.
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