≥99% HPLC Purity MS Confirmed Janoshik COA In-House SPPS 8-Region Worldwide Shipping
Compound type: Mitochondria-Encoded Peptide — CNTFR/GP130 Agonist CAS Number: 326916-66-9
What is Humanin?
Humanin is a 21-amino acid peptide encoded by a small open reading frame within the mitochondrial 12S rRNA gene — one of the first mitochondria-derived peptides (MDPs) discovered. It activates a heterotrimeric receptor complex (CNTFR/GP130/WSX-1) to drive JAK/STAT3 signalling with neuroprotective, anti-apoptotic, insulin-sensitising, and cardioprotective effects. Circulating Humanin levels decline with age and in Alzheimer’s disease. It prevents Bax-mediated mitochondrial apoptosis and reduces amyloid-β toxicity in neural models. A synthetic analogue HNG (Humanin-G) with 1000-fold greater potency is also studied.
Research Applications
Mitochondria-Derived Peptide Biology
First characterised MDP — reference compound for mitochondrial peptide research
Neuroprotection
Anti-apoptotic Bax inhibition and amyloid-β toxicity reduction in neural models
Insulin Sensitivity
JAK/STAT3-mediated insulin sensitisation in metabolic research
Aging Biomarker
Circulating Humanin declines with age — studied as longevity biomarker and intervention
Cardioprotection
Mitochondria-derived cardiac protection via CNTFR/GP130 signalling
Humanin is a 21-amino acid mitochondria-derived peptide (MDP) encoded within the mitochondrial 12S rRNA. It activates CNTFR/GP130/WSX-1 receptor complex for neuroprotection, insulin sensitisation, and cardioprotection. Humanin levels decline with age and in Alzheimer’s disease — making it a key longevity and neuroprotection research compound.
How is Humanin reconstituted?
Add 1–2mL bacteriostatic water to the lyophilized vial. Humanin dissolves readily to a clear solution. Swirl gently and store at 2–8°C for up to 21 days. Avoid freeze-thaw of reconstituted solution.
What purity is QSC Humanin?
QSC Humanin is ≥99% HPLC pure with MS-confirmed 21-amino acid identity on every batch. COA verifiable at verify.janoshik.com.
Research Use Only: All QSC compounds are sold strictly for laboratory research purposes only. Not for human consumption, veterinary use, or any other application. Researchers are responsible for compliance with local regulations.
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