≥99% HPLC Purity MS Confirmed Janoshik COA In-House SPPS 8-Region Worldwide Shipping
Compound type: Mitochondria-Encoded Peptide — CNTFR/GP130 Agonist CAS Number: 326916-66-9
What is Humanin?
Humanin is a 21-amino acid peptide encoded by a small open reading frame within the mitochondrial 12S rRNA gene — one of the first mitochondria-derived peptides (MDPs) discovered. It activates a heterotrimeric receptor complex (CNTFR/GP130/WSX-1) to drive JAK/STAT3 signalling with neuroprotective, anti-apoptotic, insulin-sensitising, and cardioprotective effects. Circulating Humanin levels decline with age and in Alzheimer’s disease. It prevents Bax-mediated mitochondrial apoptosis and reduces amyloid-β toxicity in neural models. A synthetic analogue HNG (Humanin-G) with 1000-fold greater potency is also studied.
Research Applications
Mitochondria-Derived Peptide Biology
First characterised MDP — reference compound for mitochondrial peptide research
Neuroprotection
Anti-apoptotic Bax inhibition and amyloid-β toxicity reduction in neural models
Insulin Sensitivity
JAK/STAT3-mediated insulin sensitisation in metabolic research
Aging Biomarker
Circulating Humanin declines with age — studied as longevity biomarker and intervention
Cardioprotection
Mitochondria-derived cardiac protection via CNTFR/GP130 signalling
Humanin is a 21-amino acid mitochondria-derived peptide (MDP) encoded within the mitochondrial 12S rRNA. It activates CNTFR/GP130/WSX-1 receptor complex for neuroprotection, insulin sensitisation, and cardioprotection. Humanin levels decline with age and in Alzheimer’s disease — making it a key longevity and neuroprotection research compound.
How is Humanin reconstituted?
Add 1–2mL bacteriostatic water to the lyophilized vial. Humanin dissolves readily to a clear solution. Swirl gently and store at 2–8°C for up to 21 days. Avoid freeze-thaw of reconstituted solution.
What purity is QSC Humanin?
QSC Humanin is ≥99% HPLC pure with MS-confirmed 21-amino acid identity on every batch. COA verifiable at verify.janoshik.com.
Research Use Only: All QSC compounds are sold strictly for laboratory research purposes only. Not for human consumption, veterinary use, or any other application. Researchers are responsible for compliance with local regulations.
QSC Network
Compound reference, COA verification, and regional warehouse information across the QSC network.
