≥99% HPLC Purity MS Confirmed Janoshik COA In-House SPPS 8-Region Worldwide Shipping
Compound type: Neuropeptide — OX1R/OX2R Agonist CAS Number: 205120-58-7
What is Orexin A (Hypocretin-1)?
Orexin-A (Hypocretin-1) is a 33-amino acid neuropeptide with two disulfide bridges produced by lateral hypothalamic neurons. It activates both OX1R and OX2R receptors (Gq-coupled) with high affinity, driving arousal, wakefulness, appetite, and energy homeostasis. Orexin deficiency causes narcolepsy-cataplexy syndrome in humans and canine narcolepsy models. Unlike Orexin-B (OX2R-preferring), Orexin-A has equal affinity for both receptor subtypes. Orexin-A neurons project widely including to locus coeruleus, dorsal raphe, histaminergic tuberomammillary nucleus, and ventral tegmental area, explaining its wide-ranging arousal and motivational effects.
Research Applications
Narcolepsy Models
OX1R/OX2R agonism to restore wakefulness in orexin-deficient models
Orexin-A (Hypocretin-1) is a 33-amino acid dual OX1R/OX2R agonist neuropeptide from lateral hypothalamic neurons. It regulates wakefulness, arousal, appetite, and reward. Orexin deficiency causes narcolepsy — making Orexin-A the primary research tool for sleep disorder, arousal pathway, and metabolic research.
How is Orexin-A reconstituted?
Add 1–2mL bacteriostatic water to the lyophilized vial. Orexin-A has two disulfide bridges — swirl gently and do not shake to avoid disrupting the cyclic structure. Dissolves to a clear colourless solution. Store at 2–8°C for up to 21 days.
What purity is QSC Orexin-A?
QSC Orexin-A is ≥99% HPLC pure with MS-confirmed molecular weight (3561.1 Da, two disulfide bridges confirmed) on every batch. COA verifiable at verify.janoshik.com.
Research Use Only: All QSC compounds are sold strictly for laboratory research purposes only. Not for human consumption, veterinary use, or any other application. Researchers are responsible for compliance with local regulations.
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Compound reference, COA verification, and regional warehouse information across the QSC network.
