Eloralintide vs Cagrilintide | GLP-1R/GCGR vs Amylin/AMY1R | QSC
Eloralintide vs Cagrilintide
GLP-1R/GCGR Dual Agonist vs Amylin/AMY1R — Mechanism, Data & Research Application Comparison | QSC
Factor
Eloralintide
Cagrilintide
Class
Dual GLP-1R/GCGR Agonist
Amylin/AMY1R
Mechanism
GLP-1R + GCGR co-agonism
AMY1R agonist
Best Trial Result
~10–11% wt loss · ~40–50% liver fat ↓
−15.6% CagriSema (Ph 2)
NASH / Liver Data
✓ Phase 2 — direct GCGR/CPT1A
AMY1R, not GCGR
GCGR Component
✓ Direct hepatic fat oxidation
✗
At QSC
✓ In stock — first mover
✓ In stock
Research Analysis: Different receptor classes entirely. Eloralintide: GLP-1R+GCGR — includes direct hepatic fat oxidation via CPT1A. Cagrilintide: AMY1R (amylin receptor) — central satiety via area postrema/NTS, gastric emptying slowing, distinct from GCGR. No GCGR component means no direct CPT1A hepatic fat oxidation. For GCGR/NASH biology: eloralintide. For AMY1R/amylin pathway research: cagrilintide. For combined incretin/amylin research (mimicking CagriSema): combine semaglutide+cagrilintide — also both available at QSC.
What is the difference between eloralintide and Cagrilintide?
Eloralintide is a dual GLP-1R/GCGR co-agonist; Cagrilintide is a Amylin/AMY1R. The key mechanistic difference is the presence or absence of GCGR: eloralintide’s GCGR agonism drives direct hepatic CPT1A-mediated fat oxidation — independent of body weight loss. Different receptor classes entirely. Eloralintide: GLP-1R+GCGR — includes direct hepatic fat oxidation via CPT1A. Cagrilintide: AMY1R (amylin receptor) — central satiety via area postrema/NTS, gastric emptying slowing, distinct from GCGR. No GCGR com
Which is better for NASH research: eloralintide or Cagrilintide?
For research specifically targeting direct hepatic fat oxidation via GCGR/CPT1A, eloralintide is the dedicated tool — Phase 2 data shows ~40–50% liver fat reduction, disproportionate to ~10–11% weight loss. Cagrilintide reduces liver fat secondarily via weight loss without a direct GCGR hepatic mechanism.
Are both eloralintide and Cagrilintide available at QSC?
Yes — both eloralintide and Cagrilintide are available at QSC (qscpeptide.com) at ≥99% HPLC purity with Janoshik independent COA verification. US Domestic Warehouse, 2–4 business day delivery. Researchers can source both compounds from one verified supplier for comparative protocols.
Research Use Only: Eloralintide is sold by QSC strictly for in vitro laboratory research purposes only. Not for human or veterinary use. Not FDA approved for clinical use.
