Reduces oxidative stress markers, protects neurons in ischaemia models, preserves dopaminergic/serotonergic systems
Research Questions Answered
What is Semax?
Semax (MEHFPGP) is a synthetic heptapeptide derived from ACTH 4–10 (Met-Glu-His-Phe-Pro-Gly-Pro), developed in Russia and approved there for neurological applications (stroke, TBI, optic nerve disease). It activates MC4R receptors and upregulates BDNF and NGF expression, producing neuroprotective and cognitive-enhancing effects in research models. It has been in clinical use in Russia since 1982 and represents one of the most extensively researched nootropic peptides.
How does Semax work?
Semax works through MC4R (melanocortin-4 receptor) activation → downstream BDNF and NGF gene expression upregulation → TrkB receptor signalling (neuroplasticity, LTP). It also directly modulates dopaminergic, serotonergic, and adrenergic neurotransmitter systems. The BDNF upregulation is the primary mechanism: BDNF activates TrkB → CREB phosphorylation → synaptic plasticity genes → improved learning and memory formation in research models.
What is the difference between Semax and NA-Semax Amidate?
Three forms: Semax (base), NA-Semax (N-acetylated), NA-Semax Amidate (N-acetylated + C-amidated). Each modification improves enzymatic stability. NA-Semax Amidate is the most stable and potent — longest activity window and strongest BDNF effect. Semax is the original approved form; NA-Semax Amidate is preferred for research protocols requiring maximal effect.
What is Semax used for in research?
Semax research applications: BDNF/NGF biology, neuroplasticity (LTP models), neuroprotection (ischaemia, oxidative stress), cognitive enhancement models, dopamine/serotonin system research, stroke recovery models, and comparative nootropic peptide research (Semax vs Selank, vs Cerebrolysin). Approved in Russia for stroke, TBI, and optic nerve conditions.
Where can I buy Semax for research?
Research-grade Semax is available from QSC (qscpeptide.com) at ≥99% HPLC purity with Janoshik COA. US Domestic Warehouse: 2–4 business days. Research use only.
What is the difference between Semax and Selank?
Semax: MC4R/BDNF — stimulatory/cognitive enhancement profile. Selank: GABA-A/anxiolytic — calming/anti-anxiety profile. Different mechanisms, different research endpoints. Semax increases cognitive arousal and BDNF; Selank reduces anxiety and modulates immune function. Frequently researched together as complementary CNS compounds.
What is Semax dose in research?
Published Russian clinical protocols: 1–3 drops intranasally of 0.1–1% solution (= ~75–300 mcg per dose). Animal research: 50–500 mcg/kg. For in vitro research, dose-response protocols should reference published literature. QSC provides reconstitution guidance with orders.
Is Semax approved anywhere?
Yes — Semax has been approved in Russia (Pharmsynthez) since 1982 for: ischaemic stroke, TBI, optic nerve atrophy, hypotension, and intellectual/attention deficit. It is not FDA approved. Research-grade Semax from QSC is sold for in vitro laboratory research.
How is Semax stored?
Lyophilised Semax: store at −20°C. Reconstituted: 4°C, use within 28 days. Semax is relatively stable due to its synthetic proline-rich structure. Protect from light.
What is Semax molecular weight?
Semax (MEHFPGP) has a molecular weight of approximately 887.0 Da. The base sequence is Met-Glu-His-Phe-Pro-Gly-Pro (7 amino acids). CAS number: 80714-61-0.
Where to Buy Research-Grade Semax
≥99% HPLC · Janoshik COA · US Domestic 2–4 Days · Research Use Only
