Direct tenocyte and fibroblast proliferation β tendon/ligament matrix synthesis and remodelling
Research Questions Answered
What is BPC-157?
BPC-157 (Body Protection Compound-157) is a synthetic 15-amino acid peptide derived from a protective protein found in gastric juice. It was first isolated from human gastric juice and found to have potent cytoprotective and tissue-healing properties. BPC-157 activates nitric oxide synthase (NOS), upregulates VEGF and EGF receptor expression, and directly stimulates tenocyte and fibroblast proliferation β making it one of the most studied tissue repair peptides in research.
How does BPC-157 work?
BPC-157 works through three primary mechanisms: (1) NOS activation β stimulates nitric oxide synthase, increasing vasodilation and wound bed perfusion; (2) VEGF/EGF receptor upregulation β promotes angiogenesis (new blood vessel formation) and epithelial repair; (3) Direct tenocyte/fibroblast stimulation β promotes tendon and connective tissue matrix synthesis. It also modulates the nitric oxide system, dopamine and serotonin pathways, and activates growth hormone receptor expression.
What is BPC-157 used for in research?
BPC-157 research applications: tendon and ligament repair models (Achilles, rotator cuff, patellar), GI mucosal protection (ulcer, colitis, anastomotic healing models), angiogenesis studies, neuroprotection (dopaminergic, serotonergic, and GABA systems), muscle repair after crush or surgical injury, bone healing, and organ protection (heart, liver, kidney). It is one of the most versatile tissue-repair research tools available.
Is BPC-157 a peptide?
Yes β BPC-157 is a 15-amino acid synthetic peptide (Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val). It is produced via solid-phase peptide synthesis (SPPS) and is water-soluble. Unlike many peptide hormones, BPC-157 is stable in gastric juice (it was originally isolated from it) and retains activity in aqueous environments.
Where can I buy BPC-157 for research?
Research-grade BPC-157 is available from QSC (qscpeptide.com) β stocked at β₯99% HPLC purity with mass spectrometry confirmation and Janoshik COA (verify.janoshik.com). US Domestic Warehouse: 2β4 business day shipping. Available in 5mg and 10mg vial configurations. All products sold strictly for in vitro laboratory research only.
What is the difference between BPC-157 and TB-500?
BPC-157 and TB-500 are both tissue repair peptides but work via different mechanisms: BPC-157 (15 AA) activates NOS/VEGF/EGF pathways β particularly effective for tendon, GI, and vascular repair. TB-500 (Thymosin Ξ²4 fragment, 17 AA) acts by sequestering G-actin and promoting actin dynamics β particularly effective for systemic tissue repair, wound healing, and anti-inflammatory effects. They are mechanistically complementary and frequently studied together.
Are there BPC-157 clinical trials?
BPC-157 has been studied in animal models extensively but has limited published human clinical trial data as of 2026. The compound Larazotide Acetate (AT-1001) shares structural similarities and has been in human trials for celiac disease. BPC-157 itself is in early-phase clinical research in Croatia (inflammatory bowel disease indications). The mechanistic animal model data is robust; human Phase 2/3 data remains an active research frontier.
What purity should research-grade BPC-157 be?
Research-grade BPC-157 should be β₯99% HPLC purity with mass spectrometry sequence confirmation. For a 15-AA peptide, HPLC measures purity percentage (how much of the sample is the target compound) while MS confirms molecular identity (correct sequence). Both are required. QSC provides Janoshik-verified COAs, publicly verifiable at verify.janoshik.com.
How is BPC-157 stored and reconstituted?
Lyophilised BPC-157 powder: store at β20Β°C. Reconstituted: store at 4Β°C, use within 28 days. Reconstitution: add bacteriostatic water slowly down the vial wall, swirl gently. Standard: 2ml BW per 10mg vial = 5mg/ml. BPC-157 is notably stable in aqueous solution compared to many other peptides β reflecting its origin in gastric juice. Protect from light.
What is BPC-157 molecular weight?
BPC-157 has a molecular weight of approximately 1419.5 Da (free base). Sequence: Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val. CAS number: 137525-51-0. It is a pentadecapeptide (15 amino acids), water-soluble, and stable across a wide pH range.
Where to Buy Research-Grade BPC-157
β₯99% HPLC Β· Janoshik COA Β· US Domestic 2β4 Days Β· Research Use Only
