The NAD+ / MOTS-c / 5-Amino-1MQ blend addresses the mitochondrial longevity axis from three distinct mechanistic angles simultaneously — making it one of the most comprehensive mitochondrial research combinations available from QSC.
NAD+ serves as the substrate for the sirtuin (SIRT1–7) epigenetic enzymes and PARP-1/2 DNA repair enzymes — both of which decline in activity as NAD+ levels fall with age. MOTS-c activates AMPK (the master energy sensor) via the mitochondrial ISCU1/2–HIF1α pathway, driving metabolic flexibility, mitochondrial biogenesis, and GLUT4 translocation. 5-Amino-1MQ inhibits NNMT — an enzyme that is markedly upregulated in obese adipose tissue and consumes SAM (the universal methyl donor), depleting methylation capacity and suppressing metabolic rate.
Specifications
Blend Components
NAD+ + MOTS-c + 5-Amino-1MQ
NAD+ Mechanism
SIRT1/PARP/CD38 substrate — epigenetics, DNA repair
NNMT inhibition — SAM preservation, fat metabolism
Combined Coverage
NAD metabolism + AMPK signalling + methylation/NNMT
QSC Purity
≥99% HPLC each component · Janoshik COA
Shipping
US Domestic: 2–4 days · International: 5–14 days
Frequently Asked Questions
What is the NAD+ MOTS-c 5-Amino-1MQ blend?
This three-component research blend targets mitochondrial and metabolic longevity via three distinct pathways: NAD+ (substrate for sirtuins and PARP — epigenetic and DNA repair enzymes), MOTS-c (mitochondrial-derived peptide — AMPK activation, metabolic flexibility), and 5-Amino-1MQ (NNMT inhibitor — increases SAM availability, prevents obesity-related metabolic dysfunction). Together they address NAD metabolism, AMPK signalling, and methylation simultaneously.
What is 5-Amino-1MQ?
5-Amino-1-methylquinolinium (5-Amino-1MQ) is a small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT) — an enzyme that consumes SAM (S-adenosylmethionine) and produces 1-methylnicotinamide. NNMT is upregulated in adipose tissue in obesity and is linked to energy expenditure suppression. 5-Amino-1MQ inhibition prevents SAM depletion, increases NAD+ precursor availability, and promotes fat cell differentiation suppression. Mouse data shows significant visceral fat reduction with NNMT inhibition.
Why combine NAD+, MOTS-c, and 5-Amino-1MQ?
The three compounds are mechanistically complementary and non-overlapping: NAD+ provides the substrate for SIRT1/2/3 and PARP-1 (epigenetic regulation, DNA repair). MOTS-c activates AMPK (cellular energy sensor, mitochondrial biogenesis, glucose uptake). 5-Amino-1MQ increases SAM availability and prevents NNMT-driven metabolic suppression. Each addresses a different node of the mitochondrial/metabolic longevity network — combining all three gives comprehensive research coverage.
Where can I buy this research blend?
QSC stocks NAD+, MOTS-c, and 5-Amino-1MQ individually and as a combined blend at ≥99% HPLC purity with Janoshik COA. Ships US Domestic 2–4 business days. Research use only.
Buy Research-Grade NAD+ MOTS-c 5-Amino-1MQ Blend
≥99% HPLC · Janoshik COA · US Domestic 2–4 Days · Research Use Only
Research Use Only: NAD+ MOTS-c 5-Amino-1MQ Blend is sold by QSC strictly for in vitro laboratory research. Not for human or veterinary use. Not FDA approved for clinical application.
