NA-Semax Amidate is the premium form of the Semax nootropic peptide family, combining N-terminal acetylation and C-terminal amidation to produce maximum enzymatic stability and CNS penetration. Semax itself (MEHFPGP — a synthetic heptapeptide derived from ACTH 4–10) was developed in Russia as a neuroprotective and nootropic compound, approved there for stroke and cognitive applications.
The two modifications — N-acetylation and C-amidation — prevent degradation by N-terminal aminopeptidases and C-terminal carboxypeptidases respectively, extending the peptide’s active window significantly beyond base Semax. Research shows NA-Semax Amidate produces stronger and more sustained BDNF upregulation than either Semax or NA-Semax alone, making it the preferred form for researchers studying neuroplasticity, neuroprotection, or BDNF biology.
Longest half-life and highest potency in Semax family
QSC Purity
≥99% HPLC · MS confirmed · Janoshik COA
Shipping
US Domestic: 2–4 days · International: 5–14 days
Frequently Asked Questions
What is NA-Semax Amidate?
NA-Semax Amidate is the N-acetylated, C-terminal amidated form of Semax — producing a more stable, more potent nootropic peptide. The N-acetyl group and amide modification protect the peptide from enzymatic degradation at both ends, extending its activity window and brain penetration. It is considered the most potent form of the Semax peptide family, producing superior BDNF and NGF upregulation compared to base Semax.
How does NA-Semax Amidate differ from Semax?
Three compounds exist: Semax (base), NA-Semax (N-acetylated only), and NA-Semax Amidate (N-acetylated + C-amidated). Each modification improves stability: N-acetylation protects the N-terminus from aminopeptidase degradation; amidation protects the C-terminus from carboxypeptidase degradation. NA-Semax Amidate has the longest half-life and strongest BDNF effect of the three. Research protocols requiring maximal cognitive effect use NA-Semax Amidate.
Where can I buy research-grade NA-Semax Amidate?
QSC (qscpeptide.com) stocks research-grade NA-Semax Amidate at ≥99% HPLC purity with Janoshik COA. Ships from US Domestic Warehouse in 2–4 business days. Sold for in vitro laboratory research only.
What receptors does NA-Semax Amidate act on?
NA-Semax Amidate acts on melanocortin receptors (MC4R) and upregulates BDNF (brain-derived neurotrophic factor) and NGF (nerve growth factor) expression. BDNF upregulation drives neuroplasticity, LTP (long-term potentiation), and neuroprotection via TrkB receptor signalling. The amidated form achieves these effects at lower concentrations than base Semax due to improved stability.
Buy Research-Grade NA-Semax Amidate
≥99% HPLC · Janoshik COA · US Domestic 2–4 Days · Research Use Only
Research Use Only: NA-Semax Amidate is sold by QSC strictly for in vitro laboratory research. Not for human or veterinary use. Not FDA approved for clinical application.
