Cardarine (GW501516): What It Is, How It Works & Research Data | QSC
QSC RESEARCH COMPOUND
Cardarine (GW501516)
PPARδ agonist studied for fatty acid oxidation and endurance pathway research.
≥99% HPLC Purity MS Confirmed Janoshik COA Research Use Only
What is Cardarine (GW501516)?
Cardarine (GW501516) is a non-SARM PPARδ (peroxisome proliferator-activated receptor delta) agonist that activates the transcriptional programme for fatty acid oxidation, mitochondrial biogenesis, and fast-twitch to slow-twitch fibre type switching without androgen receptor binding.
How Does Cardarine (GW501516) Work?
PPARδ binding → RXR heterodimerisation → PPRE binding → transcription of CPT1A, ACADL, FABP3 (fatty acid oxidation enzymes) and UCP3 (thermogenesis). Also upregulates PGC-1α → mitochondrial biogenesis. Mimics the transcriptional signature of endurance exercise.
Key Research
GSK preclinical data: dose-dependent fatty acid oxidation increase, improved lipid profiles, endurance enhancement in rodent models. Development abandoned by GSK due to dose/duration-dependent carcinogenicity in multi-species rodent studies at extended doses. Short-duration pathway research continues.
Cardarine (GW501516) is a non-SARM PPARδ (peroxisome proliferator-activated receptor delta) agonist that activates the transcriptional programme for fatty acid oxidation, mitochondrial biogenesis, and fast-twitch to slow-twitch fibre type switching without androgen receptor binding.
How does Cardarine (GW501516) work?
PPARδ binding → RXR heterodimerisation → PPRE binding → transcription of CPT1A, ACADL, FABP3 (fatty acid oxidation enzymes) and UCP3 (thermogenesis). Also upregulates PGC-1α → mitochondrial biogenesis. Mimics the transcriptional signature of endurance exercise.
What research has been done on Cardarine (GW501516)?
GSK preclinical data: dose-dependent fatty acid oxidation increase, improved lipid profiles, endurance enhancement in rodent models. Development abandoned by GSK due to dose/duration-dependent carcinogenicity in multi-species rodent studies at extended doses. Short-duration pathway research continues.
Where can I buy research-grade Cardarine (GW501516)?
QSC stocks research-grade Cardarine (GW501516) at ≥99% HPLC purity with Janoshik COA verification. Available in Oral capsules/tablets, 10mg with 5-region domestic US and international shipping.
What compounds are related to Cardarine (GW501516)?
Research Use Only: All QSC products are sold strictly for in vitro laboratory research. Not for human or veterinary use. Researchers are responsible for compliance with local regulations.
