Clomid (Clomiphene): What It Is, How It Works & Research Data | QSC
QSC RESEARCH COMPOUND
Clomid (Clomiphene)
SERM studied for HPG axis restoration and LH/FSH stimulation research.
≥99% HPLC Purity MS Confirmed Janoshik COA Research Use Only
What is Clomid (Clomiphene)?
Clomiphene citrate is a racemic mixture of enclomiphene (trans-isomer, pure ER antagonist) and zuclomiphene (cis-isomer, partial ER agonist). The antagonist component removes hypothalamic/pituitary negative feedback to increase GnRH pulse frequency, LH, and FSH. The agonist component provides mild oestrogenic background activity.
How Does Clomid (Clomiphene) Work?
ER antagonism at hypothalamus → removal of oestradiol negative feedback → increased GnRH pulse amplitude and frequency → anterior pituitary LH and FSH secretion increase → Leydig cell testosterone synthesis (LH-driven) and Sertoli cell/spermatogenesis support (FSH-driven).
Key Research
Well-established Phase 3 clinical data in male hypogonadism and infertility. Equivalent efficacy to exogenous testosterone for symptom resolution with maintained spermatogenesis (advantage over TRT). Also used in ovulation induction research.
Related Compounds
Researchers studying Clomid (Clomiphene) frequently also investigate: Tamoxifen, Enclomiphene, HCG, Arimidex, Raloxifene. View the complete QSC Research Manual →
Frequently Asked Questions
What is Clomid (Clomiphene)?
Clomiphene citrate is a racemic mixture of enclomiphene (trans-isomer, pure ER antagonist) and zuclomiphene (cis-isomer, partial ER agonist). The antagonist component removes hypothalamic/pituitary negative feedback to increase GnRH pulse frequency, LH, and FSH. The agonist component provides mild oestrogenic background activity.
How does Clomid (Clomiphene) work?
ER antagonism at hypothalamus → removal of oestradiol negative feedback → increased GnRH pulse amplitude and frequency → anterior pituitary LH and FSH secretion increase → Leydig cell testosterone synthesis (LH-driven) and Sertoli cell/spermatogenesis support (FSH-driven).
What research has been done on Clomid (Clomiphene)?
Well-established Phase 3 clinical data in male hypogonadism and infertility. Equivalent efficacy to exogenous testosterone for symptom resolution with maintained spermatogenesis (advantage over TRT). Also used in ovulation induction research.
Where can I buy research-grade Clomid (Clomiphene)?
QSC stocks research-grade Clomid (Clomiphene) at ≥99% HPLC purity with Janoshik COA verification. Available in Tablets, 50mg with 5-region domestic US and international shipping.
What compounds are related to Clomid (Clomiphene)?
Research Use Only: All QSC products are sold strictly for in vitro laboratory research. Not for human or veterinary use. Researchers are responsible for compliance with local regulations.
