SS-31 (Elamipretide): What It Is, How It Works & Research Data | QSC
QSC RESEARCH COMPOUND
SS-31 (Elamipretide)
Mitochondria-targeted peptide studied for cardiolipin binding and energy production.
≥99% HPLC Purity MS Confirmed Janoshik COA Research Use Only
What is SS-31 (Elamipretide)?
SS-31 (Elamipretide) is a tetrapeptide (D-Arg-2’6′-Dmt-Lys-Phe-NH₂) that selectively concentrates in the inner mitochondrial membrane via electrostatic interaction with cardiolipin. The first compound to directly target mitochondrial architecture for cytoprotective effect.
How Does SS-31 (Elamipretide) Work?
SS-31 binds cardiolipin in the inner mitochondrial membrane → stabilises cristae architecture → maintains efficient electron transport chain function → reduces ROS production → preserves ATP synthesis capacity under stress. Also prevents cytochrome c release (anti-apoptotic).
Key Research
Phase 2 cardiac data: EMBRACE-STEMI trial showed improved left ventricular function post-MI. Barth syndrome (cardiolipin deficiency disorder) trial showed significant improvement in exercise capacity. Aged skeletal muscle studies: restored mitochondrial function and exercise capacity to youthful levels.
Related Compounds
Researchers studying SS-31 (Elamipretide) frequently also investigate: MOTS-c, Methylene Blue, NAD+, Epitalon, FOXO4-DRI. View the complete QSC Research Manual →
Frequently Asked Questions
What is SS-31 (Elamipretide)?
SS-31 (Elamipretide) is a tetrapeptide (D-Arg-26-Dmt-Lys-Phe-NH₂) that selectively concentrates in the inner mitochondrial membrane via electrostatic interaction with cardiolipin. The first compound to directly target mitochondrial architecture for cytoprotective effect.
How does SS-31 (Elamipretide) work?
SS-31 binds cardiolipin in the inner mitochondrial membrane → stabilises cristae architecture → maintains efficient electron transport chain function → reduces ROS production → preserves ATP synthesis capacity under stress. Also prevents cytochrome c release (anti-apoptotic).
What research has been done on SS-31 (Elamipretide)?
Phase 2 cardiac data: EMBRACE-STEMI trial showed improved left ventricular function post-MI. Barth syndrome (cardiolipin deficiency disorder) trial showed significant improvement in exercise capacity. Aged skeletal muscle studies: restored mitochondrial function and exercise capacity to youthful levels.
Where can I buy research-grade SS-31 (Elamipretide)?
QSC stocks research-grade SS-31 (Elamipretide) at ≥99% HPLC purity with Janoshik COA verification. Available in Lyophilised powder, 10mg vial kits with 5-region domestic US and international shipping.
What compounds are related to SS-31 (Elamipretide)?
Research Use Only: All QSC products are sold strictly for in vitro laboratory research. Not for human or veterinary use. Researchers are responsible for compliance with local regulations.
