GHK-Cu: What It Is, How It Works & Research Data | QSC
QSC RESEARCH COMPOUND
GHK-Cu
Copper tripeptide studied for collagen synthesis, skin remodelling, and wound healing.
≥99% HPLC Purity MS Confirmed Janoshik COA Research Use Only
What is GHK-Cu?
GHK-Cu (glycine-histidine-lysine copper complex) is a naturally occurring tripeptide-copper complex found in human plasma, saliva, and urine. Levels decline sharply with age. Acts as a potent biological signal for tissue remodelling: upregulating collagen I, III, and IV while simultaneously regulating MMP activity to remove damaged ECM.
How Does GHK-Cu Work?
GHK-Cu binds LRP1 receptor (low-density lipoprotein receptor-related protein 1) on fibroblasts → activates PI3K/Akt signalling → upregulates collagen synthesis genes. Simultaneously modulates TGF-β1 (reduces scarring) and activates antioxidant gene expression via Nrf2.
Key Research
Pickart et al. research programme: GHK-Cu increases collagen synthesis in fibroblast cultures 6-fold. In vivo wound healing acceleration. Genome-wide analysis showing GHK-Cu modulates expression of 4,000+ genes associated with inflammation, tissue repair, and ageing.
GHK-Cu (glycine-histidine-lysine copper complex) is a naturally occurring tripeptide-copper complex found in human plasma, saliva, and urine. Levels decline sharply with age. Acts as a potent biological signal for tissue remodelling: upregulating collagen I, III, and IV while simultaneously regulating MMP activity to remove damaged ECM.
How does GHK-Cu work?
GHK-Cu binds LRP1 receptor (low-density lipoprotein receptor-related protein 1) on fibroblasts → activates PI3K/Akt signalling → upregulates collagen synthesis genes. Simultaneously modulates TGF-β1 (reduces scarring) and activates antioxidant gene expression via Nrf2.
What research has been done on GHK-Cu?
Pickart et al. research programme: GHK-Cu increases collagen synthesis in fibroblast cultures 6-fold. In vivo wound healing acceleration. Genome-wide analysis showing GHK-Cu modulates expression of 4,000+ genes associated with inflammation, tissue repair, and ageing.
Where can I buy research-grade GHK-Cu?
QSC stocks research-grade GHK-Cu at ≥99% HPLC purity with Janoshik COA verification. Available in Lyophilised powder, 50mg vial kits with 5-region domestic US and international shipping.
Research Use Only: All QSC products are sold strictly for in vitro laboratory research. Not for human or veterinary use. Researchers are responsible for compliance with local regulations.
