Retatrutide: What It Is, How It Works & Research Data | QSC
QSC RESEARCH COMPOUND
Retatrutide
Triple GLP-1/GIPR/GCGR agonist — highest weight reduction in clinical trial history.
≥99% HPLC Purity MS Confirmed Janoshik COA Research Use Only
What is Retatrutide?
Retatrutide (LY3437943) is a once-weekly triple receptor agonist targeting GLP-1R, GIPR, and glucagon receptor (GCGR) simultaneously. The addition of GCGR agonism to the dual incretin mechanism drives direct hepatic fat oxidation and brown adipose thermogenesis not achievable with GLP-1/GIP alone.
How Does Retatrutide Work?
GLP-1R: appetite suppression and insulin secretion. GIPR: adipose insulin sensitivity and cAMP synergy. GCGR: hepatic CPT1A upregulation (direct fat oxidation), BAT UCP1 expression (thermogenesis), and white adipose lipolysis. Three independent fat-reduction signals operating in parallel.
Key Research
Phase 2 (NEJM 2023): retatrutide 12mg produced −24.2% body weight at 48 weeks — the highest weight reduction ever recorded in a human pharmacological trial at any dose or duration.
Retatrutide (LY3437943) is a once-weekly triple receptor agonist targeting GLP-1R, GIPR, and glucagon receptor (GCGR) simultaneously. The addition of GCGR agonism to the dual incretin mechanism drives direct hepatic fat oxidation and brown adipose thermogenesis not achievable with GLP-1/GIP alone.
How does Retatrutide work?
GLP-1R: appetite suppression and insulin secretion. GIPR: adipose insulin sensitivity and cAMP synergy. GCGR: hepatic CPT1A upregulation (direct fat oxidation), BAT UCP1 expression (thermogenesis), and white adipose lipolysis. Three independent fat-reduction signals operating in parallel.
What research has been done on Retatrutide?
Phase 2 (NEJM 2023): retatrutide 12mg produced −24.2% body weight at 48 weeks — the highest weight reduction ever recorded in a human pharmacological trial at any dose or duration.
Where can I buy research-grade Retatrutide?
QSC stocks research-grade Retatrutide at ≥99% HPLC purity with Janoshik COA verification. Available in Lyophilised powder, 10mg and 40mg vial kits with 5-region domestic US and international shipping.
What compounds are related to Retatrutide?
Researchers studying Retatrutide frequently also investigate: Tirzepatide, Semaglutide, Cagrilintide, Survodutide.
Research-Grade Retatrutide from QSC
Available: Lyophilised powder, 10mg and 40mg vial kits | ≥99% HPLC | Janoshik COA | 5-region shipping
Research Use Only: All QSC products are sold strictly for in vitro laboratory research. Not for human or veterinary use. Researchers are responsible for compliance with local regulations.
