Semaglutide: What It Is, How It Works & Research Data | QSC
QSC RESEARCH COMPOUND
Semaglutide
GLP-1 receptor agonist studied for metabolic and weight regulation research.
≥99% HPLC Purity MS Confirmed Janoshik COA Research Use Only
What is Semaglutide?
Semaglutide is a long-acting GLP-1 receptor agonist with a C18 fatty diacid modification that extends half-life to approximately 7 days. It activates GLP-1 receptors in the pancreas (insulin secretion), hypothalamus (appetite suppression), and GI tract (gastric emptying).
How Does Semaglutide Work?
Binding GLP-1R triggers Gαs-mediated cAMP elevation, PKA activation, and downstream insulin gene transcription in beta cells. Hypothalamic GLP-1R activation reduces orexigenic NPY/AgRP signalling and increases anorexigenic POMC/CART expression.
Key Research
SUSTAIN and STEP trial programme (Phase 3): STEP 1 showed −14.9% body weight at 68 weeks vs placebo in subjects with obesity. Cardiovascular outcomes data from SUSTAIN-6.
Related Compounds
Researchers studying Semaglutide frequently also investigate: Tirzepatide, Retatrutide, Cagrilintide, Liraglutide, Orforglipron. View the complete QSC Research Manual →
Frequently Asked Questions
What is Semaglutide?
Semaglutide is a long-acting GLP-1 receptor agonist with a C18 fatty diacid modification that extends half-life to approximately 7 days. It activates GLP-1 receptors in the pancreas (insulin secretion), hypothalamus (appetite suppression), and GI tract (gastric emptying).
How does Semaglutide work?
Binding GLP-1R triggers Gαs-mediated cAMP elevation, PKA activation, and downstream insulin gene transcription in beta cells. Hypothalamic GLP-1R activation reduces orexigenic NPY/AgRP signalling and increases anorexigenic POMC/CART expression.
What research has been done on Semaglutide?
SUSTAIN and STEP trial programme (Phase 3): STEP 1 showed −14.9% body weight at 68 weeks vs placebo in subjects with obesity. Cardiovascular outcomes data from SUSTAIN-6.
Where can I buy research-grade Semaglutide?
QSC stocks research-grade Semaglutide at ≥99% HPLC purity with Janoshik COA verification. Available in Lyophilised powder, 10-vial kit (multiple doses) with 5-region domestic US and international shipping.
Research Use Only: All QSC products are sold strictly for in vitro laboratory research. Not for human or veterinary use. Researchers are responsible for compliance with local regulations.
