What is DSIP and how is it used in sleep research?
DSIP (delta sleep-inducing peptide) is a nonapeptide originally isolated from rabbit cerebral venous blood during delta sleep. It promotes NREM delta wave sleep when administered centrally or peripherally (it crosses the BBB). In sleep research, it is used with EEG to measure effects on sleep architecture, delta wave power, paradoxical sleep, and plasma cortisol patterns.
How does epitalon affect sleep research?
Epitalon is the pineal peptide bioregulator from Khavinson et al. In aged animals with disrupted melatonin production, epitalon restores melatonin synthesis and circadian rhythm. For sleep research in ageing models, epitalon addresses the melatonin production deficiency that drives circadian disruption in aged subjects.
What is the connection between GH peptides and sleep?
The majority of daily GH secretion occurs during slow-wave sleep (SWS). GH-releasing peptides administered before sleep amplify the nocturnal GH pulse. For sleep research, GHRPs/GHRH analogues are relevant when studying the relationship between sleep architecture quality and GH pulse magnitude — particularly in aged or hypogonadal models with disrupted sleep-linked GH secretion.
What EEG endpoints are used in sleep peptide research?
Standard endpoints: total sleep time, sleep onset latency, NREM stage 1/2/3 durations, SWS (delta) time, delta wave power (spectral analysis), REM sleep duration and latency, wake after sleep onset (WASO), and plasma cortisol/melatonin/GH profiles at defined sleep stage timepoints.
